Turned on by genotoxic stress

Turned on by genotoxic stress

Genomic stability is crucial to maintain cell viability and avoid errors in control of proliferation that often lead to disease. Cell cycle checkpoints have evolved as molecular mechanisms to prevent this problem. DNA damage or DNA replica-tion stress during S phase activates the intra-S phase checkpoint, which ensures faithful DNA replication by multiple mechanisms, including inducing expressi...

Plant retrotransposons: Turned on by stress

Virtually all genomes contain transposable elements. In some organisms, especially plants, transposable elements or sequences derived from them can exceed 50 % of genomic DNA. Some people believe that these elements are simply parasitic entities that flourish because they can out-replicate their host, the genome of which provides numerous safe havens both within and between genes [1]. According...

A novel p53-Cdc7 link induced by genotoxic stress.

Turned on or turned out? Campaign advertising, information and voting

Article history: Received 3 June 2009 Received in revised form 3 May 2011 Accepted 9 May 2011 Available online 16 May 2011 We present results from laboratory experimental elections in which voter information is endogenously provided by candidates and voting is voluntary. We also compare advertisements that are costless to voters with those that reduce voter payoffs. We find that informative adv...

Quantification of Cellular NEMO Content and Its Impact on NF-κB Activation by Genotoxic Stress

NF-κB essential modulator, NEMO, plays a key role in canonical NF-κB signaling induced by a variety of stimuli, including cytokines and genotoxic agents. To dissect the different biochemical and functional roles of NEMO in NF-κB signaling, various mutant forms of NEMO have been previously analyzed. However, transient or stable overexpression of wild-type NEMO can significantly inhibit NF-κB act...